Research Fund Secretariat - Detail of Approved Project (Reference No.: 02130386)

Detail of Approved Project (Reference No.: 02130386)

Fund	:	HMRF - Advanced Medical Research
Project Status	:	Closed
Reference No.	:	02130386
Project Title	:	Illuminating the functional abnormalities of brain networks underlying social communication and repetitive behaviors in Autism Spectrum Disorder (ASD): Implication on a neurobiological treatment of neurofeedback
Research Activity Code	:	Aetiology
Health Category	:	Mental health
Applicant(s)	:	LAI YCK(1) LEUNG WLP(2) CHAN ASY(2) LEE MCM(1) SHEA KS(1) MA SL(1) SO HWS(2) TSE CY(2) CHAN FCG(1) CHE KI(1)
Affiliation(s)	:	Departemnt of Psychiatry,The Chinese University of Hong Kong(1) Department of Psychology,The Chinese University of Hong Kong(2)
Approved Amount (HK$)	:	$754,538.00
Abstract	:	Objective:We propose using the event-related optical signal (EROS) to investigate the neurobiological basis of impaired social communication and repetitive behavior in ASD. Hypothesis-to-be-tested:We hypothesize 1)impairments in social communication are associated with abnormalities in the frontotemporal network during pre-attentive change detection; and 2)persistent interest is associated with reduced habituation to repeating stimuli in the auditory cortex. Design-and-subjects:Participants will watch a silent subtitled movie and be instructed to ignore the auditory stimuli that are presented. In the first experiment, three types of auditory stimuli, speech sounds, non-speech sounds, and prosody will be presented, and the automatic brain responses elicited will be recorded. In the second experiment, trains of complex tones will be presented and the habituation effect in the auditory cortex will be examined. Twenty ASD children (6-12 years old) and two groups of age and gender matched controls (ADHD and community) will be recruited. Study-instruments:The instruments include Autism Diagnostic Interview-Revised (ADI-R), the Autism Diagnostic Observation Schedule (ADOS), and the optical brain imaging machine. Main-outcome-measures:ASD symptoms will be quantified with ADI-R and ADOS. EROS will be recorded for localizing the abnormal brain activities. Data-analysis:Typical EROS pre-processing and analysis procedures will be used. Brain responses will be correlated with the symptoms measured with ADI-R and ADOS. Expected-results:We expect 1)abnormal frontotemporal activities in ASD with speech sounds or prosody in the first experiment, 2)educed habituation effect to repeating stimuli in ASD in the second experiment, and 3)significant correlation between abnormal brain activities and the severity of symptoms in both experiments.
Keywords	:
Instruments	:
Remarks	:

Dissemination Report	:
Final Report	:		02130386FR.pdf

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